Effetti dell’ambiente sui meccanismi epigenetici

2071

di Lucia Migliore

Genetica Medica, Dipartimento di Ricerca Traslazionale e Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa

Il Pediatra 2016; 5: 50-56.

Bibliografia

  1. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007 Apr; 8(4): 253-62.
  2. Barker DJ, Eriksson JG, Forsén T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002 Dec; 31(6): 1235-9.
  3. Marsit CJ Influence of environmental exposure on human epigenetic regulation. The Journal of Experimental Biology. 2015; 218: 71-79.
  4. Guil S, Esteller M. RNA-RNA interactions in gene regulation: the coding and noncoding players. Trends Biochem Sci. 2015 May; 40(5): 248-56.
  5. Lo and Zhou, Environmental alterations of epigenetics prior to the birth. Int Rev Neurobiol, 2014; 115: 1-49.
  6. Bustaffa E, Stoccoro A, Bianchi F, Migliore L. Genotoxic and epigenetic mechanisms in arsenic carcinogenicity. Arch Toxicol 2014; 88(5): 1043-67.
  7. Crews D, Gillette R, Miller-Crews I, et al. Nature, nurture and epigenetics. Mol Cell Endocrinol. 2014 Dec; 398(1-2): 42-52.
  8. http://www.iss.it/inte
  9. Heindel, et al. Parma consensus statement on metabolic disruptors Environ Health. 2015 Jun 20; 14: 54.
  10. Burgio E, Lopomo A, Migliore L. Obesity and diabetes: from genetics to epigenetics. Mol. Biol. Rep. 2015 Apr; 42(4): 799-818.
  11. Lopomo A, Burgio E, Migliore L. Epigenetics of obesity. Prog Mol Biol Transl Sci. 2016; 140: 151-84.
  12. Grün F, Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology. 2006 Jun; 147(6 Suppl): S50-5.
  13. Coppedè F. The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects. Front Genet. 2015 Jun 25; 6: 223.
  14. Laufer BI, Diehl EJ, Singh SM. Neurodevelopmental epigenetic etiologies: insights from studies on mouse models of fetal alcohol spectrum disorders. Epigenomics. 2013; 5(5): 465-8.
  15. Kleiber ML, Mantha K, Stringer RL, Singh SM. Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. J Neurodev Disord. 2013 Mar 13; 5(1): 6.
  16. Laufer BI, Kapalanga J, Castellani CA, Diehl EJ, Yan L, Singh SM. Associative DNA methylation changes in children with prenatal alcohol exposure. Epigenomics. 2015; 7(8): 1259-74.
  17. Aguilera O, Fernández AF, Muñoz A, Fraga MF. Epigenetics and environment: a complex relationship. Appl Physiol 2010; 109: 243–251.
  18. Heindel JJ, Balbus J, Birnbaum L, et al. Developmental origins of health and disease: integrating environmental influences. Endocrinology. 2015 Oct; 156(10): 3416-21.